Effectiveness of protease inhibitor monotherapy versus combination antiretroviral maintenance therapy: a meta-analysis

Publication

Effectiveness of protease inhibitor monotherapy versus combination antiretroviral maintenance therapy: a meta-analysis

Journal Paper/Review - Jul 19, 2011

Mathis Sandra, Arribas Jose, Meynard Jean-Luc, Cahn Pedro, Vernazza Pietro, Nelson Mark, Negredo Eugenia, Schechter Mauro, Pulido Federico, Khanlari Bettina, Bucher Heiner C

Citation

Mathis S, Arribas J, Meynard J, Cahn P, Vernazza P, Nelson M, Negredo E, Schechter M, Pulido F, Khanlari B, Bucher H. Effectiveness of protease inhibitor monotherapy versus combination antiretroviral maintenance therapy: a meta-analysis. PloS one 2011; 6:e22003.

Type

Journal Paper/Review (English)

Journal

PloS one 2011; 6

Publication Date

Jul 19, 2011

Issn Electronic

1932-6203

Pages

e22003

Brief description/objective

The unparalleled success of combination antiretroviral therapy (cART) is based on the combination of three drugs from two classes. There is insufficient evidence whether simplification to ritonavir boosted protease inhibitor (PI/r) monotherapy in virologically suppressed HIV-infected patients is effective and safe to reduce cART side effects and costs.