Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma

Publication

Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma

Journal Paper/Review - Sep 10, 2009

Bihl Florian, Mueller Nicolas J, Brander Christian, Flepp Markus, Speck Roberto F, Nadal David, Trojan Andreas, Bertisch Barbara, Henry Leah M, Chisholm John V, Christoph Berger, Swiss HIV Cohort Study

Citation

Bihl F, Mueller N, Brander C, Flepp M, Speck R, Nadal D, Trojan A, Bertisch B, Henry L, Chisholm J, Christoph B, Swiss HIV Cohort Study. Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma. AIDS 2009; 23:1918-22.

Type

Journal Paper/Review (English)

Journal

AIDS 2009; 23

Publication Date

Sep 10, 2009

Issn Electronic

1473-5571

Pages

1918-22

Brief description/objective

Kaposi's sarcoma-associated herpesvirus (KSHV) specific T cell responses and KSHV viremia were analyzed in seven HIV-infected patients with active Kaposi's sarcoma lesions who initiated highly active antiretroviral therapy, and were compared between patients with improved Kaposi's sarcoma and those with progressive Kaposi's sarcoma requiring further systemic chemotherapy. Patients with controlled Kaposi's sarcoma disease demonstrated undetectable Kaposi's sarcoma viremia together with KSHV-specific CD8 T cells secreting interferon-gamma and tumor necrosis factor-alpha, whereas progressors showed increasing viremia with weak or no T-cell responses. These data point toward a potential role of KSHV-specific immunity in the control of AIDS-associated Kaposi's sarcoma.