Kantonsspital St.Gallen

Variation in antiretroviral treatment (ART) coverage and virological suppression among three HIV key populations

Kamilla Grønborg Laut, Leah Shepherd, Magnus Gottfredsson, Dalibor Sedlacek, Brygida Knysz, Josip Begovac, Roxana Radoi, Brigitte Schmied, Nikoloz Chkhartishvili, Eric Florence, Matti Ristola, Gerd Fätkenheuer, Fiona Mulcahy, Patrick Schmid, Elena Kuzovatova, Dzmitry Paduta, Jelena Smidt, Pere Domingo, Janos Szlávik, Jens Lundgren, Amanda Mocroft, Ole Kirk & EuroSIDA Study Group


We assessed differences in antiretroviral treatment (ART) coverage and virological suppression across three HIV key populations, as defined by self-reported HIV transmission category: sex between men, injection drug use [IDU] and heterosexual transmission.

Multinational cohort study.

Within the EuroSIDA study, we assessed region-specific percentages of ART-coverage among those in care and virological suppression (<500 copies/mL) among those on ART,, and analyzed differences between transmission categories using logistic regression.

Among 12,872 participants followed 01/07/2014 - 30/06/2016, the percentages of ART-coverage and virological suppression varied between transmission categories, depending on geographical region (global p for interaction: p = 0.0148 for ART-coverage, p = 0.0006 for virological suppression). In Western (adjusted odds ratio [aOR] 1.41 [95% confidence interval 1.14-1.75]) and Northern Europe (aOR 1.68 [1.25-2.26]) heterosexuals were more likely to receive ART than men who have sex with men (MSM), while in Eastern Europe there was some evidence that infection through IDU (aOR 0.60 [0.31-1.14]) or heterosexual contact (aOR 0.58 [0.30-1.10]) was associated with lower odds of receiving ART. In terms of virological suppression, people infected through IDU or heterosexual contact in East Central and Eastern Europe were around half as likely as MSM to have a suppressed viral load on ART, while we observed no differences in virological suppression across transmission categories in Western and Northern Europe.

In our cohort, patterns of ART-coverage and virological suppression among key populations varied by geographical region, emphasizing the importance of tailoring HIV programmes to the local epidemic.
citation Laut K G, Shepherd L, Gottfredsson M, Sedlacek D, Knysz B, Begovac J, Radoi R, Schmied B, Chkhartishvili N, Florence E, Ristola M, Fätkenheuer G, Mulcahy F, Schmid P, Kuzovatova E, Paduta D, Smidt J, Domingo P, Szlávik J, Lundgren J, Mocroft A, Kirk O, EuroSIDA Study Group . Variation in antiretroviral treatment (ART) coverage and virological suppression among three HIV key populations. AIDS 2018;.
type journal paper/review (English)
date of publishing 04-10-2018
journal title AIDS
ISSN electronic 1473-5571
PubMed 30289816
DOI 10.1097/QAD.0000000000002035