No Effect of Pegylated Interferon-α on Total HIV-1 DNA Load in HIV-1/HCV Coinfected Patients
Victoria P Strouvelle, Dominique L Braun, Valentina Vongrad, Alexandra U Scherrer, Yik Lim Kok, Roger D Kouyos, Marcel Stöckle, Andri Rauch, Katharine Darling, Matthias Hoffmann, Karin J Metzner, Huldrych F Günthard & Zurich Primary HIV Infection Study And The Swiss HIV Cohort Study
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abstract
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Pegylated interferon-alpha (pIFN-α) is suggested to lower
human immunodeficiency virus type-1 (HIV-1) DNA load in
antiretroviral therapy (ART)-treated patients. We studied kinetics
of HIV-1 DNA levels in 40 HIV-1/hepatitis C virus (HCV) coinfected
patients, treated with pIFN-α for HCV and categorized into 3
groups according to start of ART: chronic HIV-1 infection (n = 22),
acute HIV-1 infection (n = 8), no-ART (n = 10). Total HIV-1 DNA
levels in 247 peripheral blood mononuclear cell samples were stable
before, during, and after pIFN-α treatment in all groups. Our
results question the benefit of pIFN-α as an immunotherapeutic
agent for reducing the HIV-1 reservoir.
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citation
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Strouvelle V P, Braun D L, Vongrad V, Scherrer A U, Kok Y L, Kouyos
R D, Stöckle M, Rauch A, Darling K, Hoffmann M, Metzner K J,
Günthard H F, Zurich Primary HIV Infection Study And The Swiss HIV
Cohort Study . No Effect of Pegylated Interferon-α on Total HIV-1
DNA Load in HIV-1/HCV Coinfected Patients. J Infect Dis 2018;
217:1883-1888.
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type
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journal paper/review (English)
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date of publishing
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25-5-2018
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journal title
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J Infect Dis (217/12)
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ISSN electronic
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1537-6613
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pages
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1883-1888
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PubMed
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29528417
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DOI
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10.1093/infdis/jiy131
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