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No Effect of Pegylated Interferon-α on Total HIV-1 DNA Load in HIV-1/HCV Coinfected Patients

Victoria P Strouvelle, Dominique L Braun, Valentina Vongrad, Alexandra U Scherrer, Yik Lim Kok, Roger D Kouyos, Marcel Stöckle, Andri Rauch, Katharine Darling, Matthias Hoffmann, Karin J Metzner, Huldrych F Günthard & Zurich Primary HIV Infection Study And The Swiss HIV Cohort Study

abstract Pegylated interferon-alpha (pIFN-α) is suggested to lower human immunodeficiency virus type-1 (HIV-1) DNA load in antiretroviral therapy (ART)-treated patients. We studied kinetics of HIV-1 DNA levels in 40 HIV-1/hepatitis C virus (HCV) coinfected patients, treated with pIFN-α for HCV and categorized into 3 groups according to start of ART: chronic HIV-1 infection (n = 22), acute HIV-1 infection (n = 8), no-ART (n = 10). Total HIV-1 DNA levels in 247 peripheral blood mononuclear cell samples were stable before, during, and after pIFN-α treatment in all groups. Our results question the benefit of pIFN-α as an immunotherapeutic agent for reducing the HIV-1 reservoir.
   
citation Strouvelle V P, Braun D L, Vongrad V, Scherrer A U, Kok Y L, Kouyos R D, Stöckle M, Rauch A, Darling K, Hoffmann M, Metzner K J, Günthard H F, Zurich Primary HIV Infection Study And The Swiss HIV Cohort Study . No Effect of Pegylated Interferon-α on Total HIV-1 DNA Load in HIV-1/HCV Coinfected Patients. J Infect Dis 2018; 217:1883-1888.
   
type journal paper/review (English)
date of publishing 25-5-2018
journal title J Infect Dis (217/12)
ISSN electronic 1537-6613
pages 1883-1888
PubMed 29528417
DOI 10.1093/infdis/jiy131