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Population-based outcome analysis of diffuse large B-cell lymphoma in people living with HIV infection and competent individuals

Annarita Conconi, Emanuele Zucca, Gloria Margiotta-Casaluci, Katharine Darling, Barbara Hasse, Manuel Battegay, Cornelia Staehelin, Urban Novak, Patrick Schmid, Alexandra Scherrer, Stephan Dirnhofer, Ivo Kwee, Luca Nassi, Franco Cavalli, Gianluca Gaidano, Francesco Bertoni, Enos Bernasconi & Swiss HIV Cohort Study (SHCS)

abstract The prognostic factors and outcome of 58 acquired immunodeficiency syndrome-related diffuse large B-cell lymphoma (AR-DLBCL) patients from the Swiss HIV Cohort Study, diagnosed from 2004 to 2011, were compared with those of 326 immunocompetent (IC)-DLBCL from the Hematology Division of the Amedeo Avogadro University (Italy) and the Oncology Institute of Southern Switzerland. Median follow-up was 6 years; 5-year overall survival (OS) was 68% (95% CI: 63%-73%) in IC-DLBCL and 63% (95% CI: 49%-75%) in AR-DLBCL (P = .220). The acquired immunodeficiency syndrome-related lymphoma international prognostic index predicted OS in AR-DLBCL. Among 148 patients younger than 61 years (40 AR-DLBCL and 108 IC-DLBCL) treated with RCHOP/RCHOP-like regimens, 20 IC-DLBCL and 9 AR-DLBCL patients died and OS was not significantly different. A higher proportion of early deaths occurred in the AR-DLBCL: indeed, 1-year OS was 94% (95% CI: 87%-97%) in IC-DLBCL and 82% (95% CI: 66%-91%) in AR-DLBCL patients. After rituximab and active antiretroviral therapy introduction, AR-DLBCL and IC-DLBCL patients treated with curative intent have similar long-term survival.
   
citation Conconi A, Zucca E, Margiotta-Casaluci G, Darling K, Hasse B, Battegay M, Staehelin C, Novak U, Schmid P, Scherrer A, Dirnhofer S, Kwee I, Nassi L, Cavalli F, Gaidano G, Bertoni F, Bernasconi E, Swiss HIV Cohort Study (SHCS) . Population-based outcome analysis of diffuse large B-cell lymphoma in people living with HIV infection and competent individuals. Hematol Oncol 2018;.
   
type journal paper/review (English)
date of publishing 16-08-2018
journal title Hematol Oncol
ISSN electronic 1099-1069
PubMed 30113708
DOI 10.1002/hon.2536