Detection of microbial colonization of the urinary tract of patients prior to secondary ureterorenoscopy is highly variable between different types of assessment: results of a prospective observational study
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abstract
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This study compares the findings of different detection methods for
microorganisms in patients with ureteral stents undergoing secondary
ureterorenoscopy including the use of a novel validated examination
pipeline for biofilms on ureteral stents. Of the included 94
patients, 21.3% showed bacteriuria in preoperative urine cultures.
Intraoperative urine culture showed bacteriuria in four (4.3%) of
the patients. Stent biofilm cultures were positive in 12.9% and qPCR
detected bacterial DNA in 18.1%. The findings of the different
examinations were poorly correlated with each other. Detection of
microorganisms in the urinary tract of patients with indwelling
ureteral stents is highly dependent on timing (i.e. pre-
intraoperative) and method of assessment. Preoperative routine urine
cultures are not predictive for intraoperative urine- and stent
culture. These results cast doubt on the clinical relevance of
enterococcal species, staphylococci, and streptococci if identified
preoperatively prior to stent removal. The timing of oral
preoperative antibiotic prophylaxis might need to be reconsidered.
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citation
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Zumstein V, Betschart P, Buhmann M T, Albrich W, Nolte O, Guesewell
S, Engeler D S, Schmid H P, Ren Q, Abt D. Detection of microbial
colonization of the urinary tract of patients prior to secondary
ureterorenoscopy is highly variable between different types of
assessment: results of a prospective observational study. Biofouling
2019;1-10.
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type
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journal paper/review (English)
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date of publishing
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27-11-2019
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journal title
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Biofouling
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ISSN electronic
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1029-2454
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pages
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1-10
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PubMed
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31775538
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DOI
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10.1080/08927014.2019.1692000
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