Multi-fungal sepsis and mucormycosis of the central nervous system in a patient treated with ibrutinib, a case report and review of the literature
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abstract
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We report the case of a 71 years old patient with chronic
lymphocytic leukemia (CLL), who developed a rapidly progressing
multi-fungal infection including mucormycosis of the central nervous
system (CNS) during treatment with ibrutinib. On autopsy mucorales
species were demonstrated intravascularly by histomorphology of
several organs and lymph nodes and were characterized as by
polymerase-chain reaction (PCR) - analysis. In addition, invasive
pulmonary was found and also confirmed by PCR. To the best of our
knowledge, this is the first confirmation of a multi-fungal sepsis
and invasive CNS-infection with mucorales species under ibrutinib.
Knowing the risk for invasive fungal disease in patients under
ibrutinib, identifying the pathogen and early initiation of specific
treatment is crucial for a good clinical outcome especially in
mucormycosis.
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citation
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Fehr M, Cathomas G, Graber A, Markert E, Gaus E, Boggian K.
Multi-fungal sepsis and mucormycosis of the central nervous system
in a patient treated with ibrutinib, a case report and review of the
literature. Med Mycol Case Rep 2019; 27:14-16.
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type
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journal paper/review (English)
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date of publishing
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3-12-2019
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journal title
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Med Mycol Case Rep (27)
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ISSN print
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2211-7539
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pages
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14-16
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PubMed
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31890489
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DOI
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10.1016/j.mmcr.2019.12.005
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contact
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Katia Boggian
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