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Burden, epidemiology, and outcomes of microbiologically confirmed respiratory viral infections in solid organ transplant recipients: a nationwide, multi-season prospective cohort study

Matteo Mombelli, Brian M Lang, Dionysios Neofytos, John-David Aubert, Christian Benden, Christoph Berger, Katia Boggian, Adrian Egli, Paola M Soccal, Laurent Kaiser, Cédric Hirzel, Manuel Pascual, Michael Koller, Nicolas J Mueller, Christian Van Delden, Hans H Hirsch, Oriol Manuel & Swiss Transplant Cohort Study

abstract Solid organ transplant (SOT) recipients are exposed to respiratory viral infection (RVI) during seasonal epidemics; however, the associated burden of disease has not been fully characterized. We describe the epidemiology and outcomes of RVI in a cohort enrolling 3294 consecutive patients undergoing SOT from May 2008 to December 2015 in Switzerland. Patient and allograft outcomes, and RVI diagnosed during routine clinical practice were prospectively collected. Median follow-up was 3.4 years (interquartile range 1.61-5.56). Six-hundred-ninety-six RVI were diagnosed in 151/334 (45%) lung and 265/2960 (5%) non-lung transplant recipients. Cumulative incidence was 60% (95% confidence interval [CI] 53%-69%) in lung and 12% (95% CI 11%-14%) in non-lung transplant recipients. RVI led to 17.9 (95% CI 15.7-20.5) hospital admissions per 1000 patient-years. Intensive care unit admission was required in 4% (27/691) of cases. Thirty-day all-cause case fatality rate was 0.9% (6/696). Using proportional hazard models we found that RVI (adjusted-hazard ratio [aHR] 2.45; 95% CI 1.62-3.73), lower respiratory tract RVI (aHR 3.45; 95% CI 2.15-5.52), and influenza (aHR 3.57; 95% CI 1.75-7.26) were associated with graft failure or death. In this cohort of SOT recipients, RVI caused important morbidity and may affect long-term outcomes, underlying the need for improved preventive strategies.
   
citation Mombelli M, Lang B M, Neofytos D, Aubert J D, Benden C, Berger C, Boggian K, Egli A, Soccal P M, Kaiser L, Hirzel C, Pascual M, Koller M, Mueller N J, van Delden C, Hirsch H H, Manuel O, Swiss Transplant Cohort Study . Burden, epidemiology, and outcomes of microbiologically confirmed respiratory viral infections in solid organ transplant recipients: a nationwide, multi-season prospective cohort study. Am J Transplant 2020;.
   
type journal paper/review (English)
date of publishing 31-10-2020
journal title Am J Transplant
ISSN electronic 1600-6143
PubMed 33131188
DOI 10.1111/ajt.16383