Immunohistochemical investigations on the course of astroglial GFAP expression following human brain injury

Publication

Immunohistochemical investigations on the course of astroglial GFAP expression following human brain injury

Journal Paper/Review - Jan 1, 2000

Hausmann Roland, Riess R, Fieguth A, Betz P

Units

Rechtsmedizin

PubMed

10741479

Citation

Hausmann R, Riess R, Fieguth A, Betz P. Immunohistochemical investigations on the course of astroglial GFAP expression following human brain injury. Int J Legal Med 2000; 113:70-5.

Type

Journal Paper/Review (English)

Journal

Int J Legal Med 2000; 113

Publication Date

Jan 1, 2000

Issn Print

0937-9827

Pages

70-5

Brief description/objective

The course of GFAP expression by astrocytes has been immunohistochemically investigated during the first 30 weeks after human brain injury. In order to provide reliable data for a forensic wound age estimation, a quantitative morphometric analysis was performed considering the different topographic regions of the cortex as well as of the white matter. Compared to the GFAP immunoreactivity in unaltered control tissue, significantly increased numbers of GFAP positive astroglial cells could be detected adjacent to the cortical contusion from 1 day up to 4 weeks after brain injury.