Publication
Modification of guanine residues in PNA-synthesis by PyBOP
Journal Paper/Review - Aug 14, 2006
Pritz Stefan, Wolf Yvonne, Klemm Clementine, Bienert Michael
Units
Contact
Citation
Pritz S, Wolf Y, Klemm C, Bienert M. Modification of guanine residues in PNA-synthesis by PyBOP. Tetrahdron Letters 2006; 47:5893-5896.
Type
Journal Paper/Review (Deutsch)
Journal
Tetrahdron Letters 2006; 47
Publication Date
Aug 14, 2006
Pages
5893-5896
Brief description/objective
The phosphonium-type coupling reagent PyBOP, when applied to the synthesis of peptide nucleic acid (PNA) oligomers, was found to form O4-phosphonium compounds of the nucleobase guanine which can be converted into C4-modified guanine-derived PNAs by nucleophiles.