New psychoactive substances—Designer benzodiazepines
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abstract
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Designer benzodiazepines are a rather new class of new psychoactive
substances counting 26 compounds by the end of 2019. However, due to
their high habit-forming potential, the easy availability of these
drugs in online shops is rather alarming. While the risk of acute
health effects or intoxications after the sole consumption of
benzodiazepines is low, combined consumption with other central
nervous system depressant drugs such as opioids or alcohol can lead
to life-threating conditions. Furthermore, long term use can lead to
tolerance and addiction. In this review article the emergence of
this drug class is described and the literature on pharmacokinetics
and the various methods of detection is discussed. Furthermore, the
structure activity relationships of benzodiazepines are summarized
in order to predict the potency of newly emerging compounds.
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keywords
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Toxicology > New Psychoactive Substances |
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citation
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Moosmann B. New psychoactive substances—Designer benzodiazepines.
WIREs Forensic Science 2021; 3:1416-1439.
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type
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journal paper/review (English)
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date of publishing
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28-3-2021
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journal title
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WIREs Forensic Science (3/6)
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publisher
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Wiley (Hoboken, NJ, USA)
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pages
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1416-1439
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DOI
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10.1002/wfs2.1416
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link
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https://wires.onlinelibrary.wiley.com/doi/abs/10.1002/wfs2.1416
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contact
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Björn Moosmann
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additional links & downloads
