Publication
Midregional pro-A-type natriuretic peptide for the evaluation of exercise intolerance
Journal Paper/Review - Dec 22, 2009
Maeder Micha, Bergmann Andreas, Morgenthaler Nils G, Reichlin Tobias, Potocki Mihael, Schaub Nora, Breidthardt Tobias, Noveanu Markus, Staub Daniel, Christ Andreas, Brutsche Martin, Mueller Christian
Units
PubMed
Doi
Citation
Type
Journal
Publication Date
Issn Electronic
Brief description/objective
The aim of this study was to determine the accuracy of midregional pro-A-type natriuretic peptide (MR-proANP) for the identification of a cardiocirculatory exercise limitation (CL) as assessed by cardiopulmonary exercise testing (CPET) and to compare it to B-type natriuretic peptide (BNP). Among 94 patients with CPET data fulfilling criteria for appropriate effort and sufficient diagnostic certainty, 27 (29%) had CL. The areas under the receiver-operator-characteristic curve for MR-proANP and BNP to identify CL were 0.84 and 0.79 respectively (p=0.17). In conclusion, MR-proANP had a comparable accuracy to BNP for the identification of CL and might be a valuable assistance for the differentiation of exercise intolerance.