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Design of the Swiss Atrial Fibrillation Cohort Study (Swiss-AF): structural brain damage and cognitive decline among patients with atrial fibrillation

David Conen, Nicolas Rodondi, Andreas Mueller, Juerg Beer, Angelo Auricchio, Peter Ammann, Daniel Hayoz, Richard Kobza, Giorgio Moschovitis, Dipen Shah, Juerg Schlaepfer, Jan Novak, Marcello Di Valentino, Paul Erne, Christian Sticherling, Leo Bonati, Georg Ehret, Laurent Roten, Urs Fischer, Andreas Monsch, Christoph Stippich, Jens Wuerfel, Matthias Schwenkglenks, Michael Kuehne & Stefan Osswald

abstract

BACKGROUND
Several studies found that patients with atrial fibrillation (AF) have an increased risk of cognitive decline and dementia over time. However, the magnitude of the problem, associated risk factors and underlying mechanisms remain unclear.

METHODS
This article describes the design and methodology of the Swiss Atrial Fibrillation (Swiss-AF) Cohort Study, a prospective multicentre national cohort study of 2400 patients across 13 sites in Switzerland. Eligible patients must have documented AF. Main exclusion criteria are the inability to provide informed consent and the presence of exclusively short episodes of reversible forms of AF. All patients undergo extensive phenotyping and genotyping, including repeated assessment of cognitive functions, quality of life, disability, electrocardiography and cerebral magnetic resonance imaging. We also collect information on health related costs, and we assemble a large biobank. Key clinical outcomes in Swiss-AF are death, stroke, systemic embolism, bleeding, hospitalisation for heart failure and myocardial infarction. Information on outcomes and updates on other characteristics are being collected during yearly follow-up visits.

RESULTS
Up to 7 April 2017, we have enrolled 2133 patients into Swiss-AF. With the current recruitment rate of 15 to 20 patients per week, we expect that the target sample size of 2400 patients will be reached by summer 2017.

CONCLUSION
Swiss-AF is a large national prospective cohort of patients with AF in Switzerland. This study will provide important new information on structural and functional brain damage in patients with AF and on other AF related complications, using a large variety of genetic, phenotypic and health economic parameters.
   
citation Conen D, Rodondi N, Mueller A, Beer J, Auricchio A, Ammann P, Hayoz D, Kobza R, Moschovitis G, Shah D, Schlaepfer J, Novak J, Di Valentino M, Erne P, Sticherling C, Bonati L, Ehret G, Roten L, Fischer U, Monsch A, Stippich C, Wuerfel J, Schwenkglenks M, Kuehne M, Osswald S. Design of the Swiss Atrial Fibrillation Cohort Study (Swiss-AF): structural brain damage and cognitive decline among patients with atrial fibrillation. Swiss Med Wkly 2017; 147:w14467.
   
type journal paper/review (English)
date of publishing 11-07-2017
journal title Swiss Med Wkly (147)
ISSN electronic 1424-3997
pages w14467
PubMed 28695548
DOI 10.4414/smw.2017.14467