Usefulness of Genetic Testing in Sudden Cardiac Arrest Survivors With or Without Previous Clinical Evidence of Heart Disease
Babken Asatryan, André Schaller, Jens Seiler, Helge Servatius, Fabian Noti, Samuel H Baldinger, Hildegard Tanner, Laurent Roten, Roger Dillier, Anna Lam, Andreas Haeberlin, Giulio Conte, Ardan M Saguner, Stephan Andreas Müller, Firat Duru, Angelo Auricchio, Peter Ammann, Christian Sticherling, Haran Burri, Tobias Reichlin, Matthias Wilhelm & Argelia Medeiros-Domingo
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abstract
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Genetic testing in survivors of sudden cardiac arrest (SCA) with a
suspicious cardiac phenotype is considered clinically useful,
whereas its value in the absence of phenotype is disputed. We aimed
to evaluate the clinical utility of genetic testing in survivors of
SCA with or without cardiac phenotype. Sixty unrelated SCA survivors
(median age: 34 [interquartile range 20 to 43] years, 82% male)
without coronary artery disease were included: 24 (40%) with
detectable cardiac phenotype (Ph(+)SCA) after the SCA event and 36
(60%) with no clear cardiac phenotype (Ph(-)SCA). The targeted exome
sequencing was performed using the TruSight-One Sequencing Panel
(Illumina). Variants in 185 clinically relevant cardiac genes with
minor allele frequency <1% were analyzed. A total of 32
pathogenic or likely pathogenic variants were found in 27 (45%)
patients: 17 (71%) in the Ph(+)SCA group and 10 (28%) in the
Ph(-)SCA group. Sixteen (67%) Ph(+)SCA patients hosted mutations
congruent with the suspected phenotype, in which 12 (50%) were
cardiomyopathies and 4 (17%) channelopathies. In Ph(-)SCA cases, 6
(17%) carried a mutation in cardiac ion channel genes that could
explain the event. The additional 4 (11%) mutations in this group,
could not explain the phenotype and require additional studies. In
conclusion, cardiac genetic testing was positive in nearly 2/3
patients of the Ph(+)SCA group and in 1/6 of the Ph(-)SCA group. The
test was useful in both groups to identify or confirm an inherited
heart disease, with an important impact on the patient care and
first-degree relatives at risk.
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citation
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Asatryan B, Schaller A, Seiler J, Servatius H, Noti F, Baldinger S
H, Tanner H, Roten L, Dillier R, Lam A, Haeberlin A, Conte G,
Saguner A M, Müller S A, Duru F, Auricchio A, Ammann P, Sticherling
C, Burri H, Reichlin T, Wilhelm M, Medeiros-Domingo A. Usefulness of
Genetic Testing in Sudden Cardiac Arrest Survivors With or Without
Previous Clinical Evidence of Heart Disease. Am J Cardiol 2019;
123:2031-2038.
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type
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journal paper/review (English)
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date of publishing
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18-03-2019
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journal title
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Am J Cardiol (123/12)
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ISSN electronic
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1879-1913
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pages
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2031-2038
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PubMed
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30975432
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DOI
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10.1016/j.amjcard.2019.02.061
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