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Heavy Drinking Habits Are Associated with Worse In-Hospital Outcomes in Patients with Acute Coronary Syndrome: An Insight from the AMIS Plus Registry

Gregorio Tersalvi, Luigi Biasco, Dragana Radovanovic, Hans Rickli, Marco Roffi, Franz Eberli, Marco Moccetti, Raban Jeger, Tiziano Moccetti, Paul Erne & Giovanni Pedrazzini

abstract

BACKGROUND
The association between alcohol consumption and the occurrence of coronary heart disease is well described in the literature, while data regarding the impact of regular alcohol consumption on in-hospital outcomes in the setting of acute coronary syndrome (ACS) are lacking. We aimed to evaluate the impact of self-reported alcohol consumption on in-hospital outcomes in patients with ACS.

METHODS
Data derived from patients enrolled between 2007 and 2019 in the Acute Myocardial Infarction in Switzerland (AMIS) Plus registry were retrospectively analyzed. Patients were stratified based on alcohol drinking pattern. Primary outcome was all-cause in-hospital mortality, while secondary outcomes were set as incidence of major adverse cardiac and cerebrovascular events (MACCEs). Outcome comparisons according to quantity of daily alcohol intake were also performed.

RESULTS
Records concerning alcohol consumption were available in 25,707 patients; 5,298 of them (21%) fulfilled the criteria of regular alcohol consumption. Regular drinkers were predominantly male, younger, smokers, more comorbid and with a worse clinical presentation as compared with abstainers/occasional drinkers. Daily alcohol intake was reported in 4,059 (77%) of these patients (regular drinkers). Among them, 2,640 were light drinkers (≤2 drinks/day) and 1,419 heavy drinkers (>2 drinks/day). In-hospital mortality and MACCEs of heavy drinkers were significantly higher compared with those of light drinkers (5.4 vs. 3.3% and 7.0 vs. 4.4%, both p = 0.001). When tested together with Global Registry of Acute Coronary Events risk score parameters, heavy alcohol consumption was independently associated with in-hospital mortality (p = 0.004).

CONCLUSIONS
Our results support that heavy alcohol consumption is an independent predictor of in-hospital mortality in patients presenting with ACS.
   
citation Tersalvi G, Biasco L, Radovanovic D, Rickli H, Roffi M, Eberli F, Moccetti M, Jeger R, Moccetti T, Erne P, Pedrazzini G. Heavy Drinking Habits Are Associated with Worse In-Hospital Outcomes in Patients with Acute Coronary Syndrome: An Insight from the AMIS Plus Registry. Cardiology 2020; 145:757-765.
   
type journal paper/review (English)
date of publishing 20-08-2020
journal title Cardiology (145/12)
ISSN electronic 1421-9751
pages 757-765
PubMed 32818933
DOI 10.1159/000508928