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Myocardial blood flow and cardiac sympathetic innervation in young adults late after arterial switch operation for transposition of the great arteries

Mathias Possner, Ronny R Buechel, Jan Vontobel, Fran Mikulicic, Christoph Gräni, Dominik C Benz, Olivier F Clerc, Tobias A Fuchs, Daniel Tobler, Dominik Stambach, Matthias Greutmann & Philipp A Kaufmann

abstract

BACKGROUND
The arterial switch operation (ASO) for repair of transposition of the great arteries (TGA) requires transection of the great arterial trunks and re-implantation of the coronary arteries into the neoaortic root resulting in cardiac sympathetic denervation which may affect myocardial blood flow (MBF) regulation. The aims of the present study were to evaluate sympathetic (re-)innervation in young adults after ASO and its impact on MBF.

METHODS
Twelve patients (age 22.5 ± 2.6 years) after ASO for TGA in the neonatal period and ten healthy controls (age 22.0 ± 1.7 years) were included. Positron emission tomography (PET) was used for measuring cardiac sympathetic innervation with [C]meta-hydroxyephedrine (mHED) and MBF with [O]HO PET at rest, during adenosine stimulation, and during sympathetic stimulation with cold pressor test. Cold pressor-induced MBF response capacity was calculated as maximal global MBF over peak rate-pressure product multiplied by 10'000.

RESULTS
Global [C]mHED uptake was significantly lower in patients compared to controls (7.0 ± 2.3 versus 11.8 ± 2.1%/min, p < 0.001). Global MBF was lower in patients compared to controls at rest and during adenosine-induced hyperemia (0.66 ± 0.08 versus 0.82 ± 0.15 ml/min/g, p = 0.005; 2.23 ± 1.19 versus 3.36 ± 1.04 ml/min/g, p = 0.030, respectively). Interestingly, MBF during cold pressor test did not differ between patients and controls (0.99 ± 0.20 versus 1.07 ± 0.16 ml/min/g, p = 0.330). However, cold pressor-induced MBF response capacity was significantly lower for patients as compared to controls (1.09 ± 0.35 versus 1.44 ± 0.39 ml/g/10,000 mmHg, p = 0.040).

CONCLUSIONS
With only partial sympathetic re-innervation of the coronary arteries, maximal dilator capacity of the coronary microvasculature and cold pressor-induced MBF response capacity remain substantially impaired in young adults after ASO compared to healthy controls.
   
citation Possner M, Buechel R R, Vontobel J, Mikulicic F, Gräni C, Benz D C, Clerc O F, Fuchs T A, Tobler D, Stambach D, Greutmann M, Kaufmann P A. Myocardial blood flow and cardiac sympathetic innervation in young adults late after arterial switch operation for transposition of the great arteries. Int J Cardiol 2019; 299:110-115.
   
type journal paper/review (English)
date of publishing 13-07-2019
journal title Int J Cardiol (299)
ISSN electronic 1874-1754
pages 110-115
PubMed 31337551
DOI 10.1016/j.ijcard.2019.07.041