Kantonsspital St.Gallen

Cartilage cell proliferation in degenerative TFCC wrist lesions

Frank Unglaub, Susanne B Thomas, Maya B Wolf, Adrian Dragu, Markus Kroeber, Thomas Mittlmeier & Raymund E Horch

abstract INTRODUCTION: The central zone of the triangular fibrocartilage complex (TFCC) of the wrist is thought to be avascular and is generally considered to lack any healing potential. AIM: The purpose of this study was to investigate, if cartilage cells of degenerative disc lesions possess any healing or proliferation potential and whether ulna length plays a significant role in the proliferation process. RESULTS: Cells positive for proliferating cell nuclear antigen (PCNA) were found in all specimens. Specimens of patients with ulna positive variance showed a decreased number of PCNA positive cells than specimens of patients with either negative or neutral ulna variance. CONCLUSION: We found that cartilage cells of Palmer type 2C lesions undergo mitotic cell division, thus exhibiting proliferation capability. It could not be shown that ulnar length is significantly correlated with the number of PCNA positive cells.
citation Unglaub F, Thomas S B, Wolf M B, Dragu A, kroeber m, Mittlmeier T, Horch R E. Cartilage cell proliferation in degenerative TFCC wrist lesions. Archives of orthopaedic and trauma surgery 2009;.
type journal paper/review (English)
date of publishing 5-5-2009
journal title Archives of orthopaedic and trauma surgery
ISSN electronic 1434-3916
PubMed 19415312
DOI 10.1007/s00402-009-0883-z