Management of musculoskeletal tumors during pregnancy: a retrospective study
Lukas K Postl, Guntmar Gradl, Rüdiger Von Eisenhart-Rothe, Andreas Toepfer, Florian Pohlig, Rainer Burgkart, Hans Rechl & Chlodwig Kirchhoff
abstract
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BACKGROUND
In recent years, scientific research has increasingly focused on
malignancies during pregnancy. However, the development of
musculoskeletal tumors during pregnancy has only been the subject of
a few studies so far. The primary aim of this study was to identify
the incidence of sarcomas during pregnancy at our musculoskeletal
tumor center (MSTC). Secondarily we intended to analyze these cases
and discuss possible recommendations regarding diagnostic work-up as
well as therapy on the basis of the literature.
METHODS
All female patients who had been treated for soft tissue or bone
sarcoma at our academic MSTC in the period between the years 2002
and 2010 were screened retrospectively for anamnestic annotations of
pregnancy or records of pregnancy in the obstetrical database of our
university hospital. The patients who met the criteria for inclusion
(diagnosed sarcoma and pregnancy) were enrolled. For every pregnant
patient two age-matched female control patients that suffered from
tumors with the same histologic type were included.
RESULTS
In the period between 2002 and 2010, 240 female patients between the
age of 16 and 45 were treated for sarcoma. In eight out of the 240
cases the tumor disease developed or progressed during pregnancy.
The delay in diagnosis was approximately eight months and turned out
to be significantly higher for pregnant patients compared to non-
pregnant controls. Each woman's tumor was misdiagnosed at least
once.
CONCLUSIONS
Diagnostic follow-up of pregnant women presenting with a growing or
painful mass, which is suspected to be a musculoskeletal tumor,
should be performed at a specialized tumor center. We recommend a
multidisciplinary approach and discussing all possible consequences
for mother and child intensively in accordance with the available
literature.
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citation
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Postl L K, Gradl G, von Eisenhart-Rothe R, Toepfer A, Pohlig F,
Burgkart R, Rechl H, Kirchhoff C. Management of musculoskeletal
tumors during pregnancy: a retrospective study. BMC Womens Health
2015; 15:48.
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type
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journal paper/review (English)
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date of publishing
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10-06-2015
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journal title
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BMC Womens Health (15)
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ISSN electronic
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1472-6874
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pages
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48
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PubMed
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26059904
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DOI
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10.1186/s12905-015-0204-3
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