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Do human tumor-associated viruses play a role in the development of synovial sarcoma?

Ulrich Lenze, Florian Pohlig, Heinrich Mühlhofer, Florian Lenze, Andreas Toepfer, Hans Rechl, Rainer Burgkart, Rüdiger Von Eisenhart-Rothe & Melanie Straub

abstract

BACKGROUND
To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role in the development of synovial sarcomas.

FINDINGS
In total 41 synovial sarcomas were included in this retrospective study. For detection of EBV 1/2 and HHV-8, resection specimens were analyzed with regard to virus-specific sequences using a SingleStep PCR. HPV analysis was carried out by an HPV-specific multiplex-PCR and subsequent array-hybridization for HPV-typing. No virus-specific DNA of EBV, HHV-8 or HPV was detected.

CONCLUSION
An involvement of these viruses in the etiology of synovial sarcoma was not detected but further studies are needed with different virus types and sarcoma entities.
   
citation Lenze U, Pohlig F, Mühlhofer H, Lenze F, Toepfer A, Rechl H, Burgkart R, von Eisenhart-Rothe R, Straub M. Do human tumor-associated viruses play a role in the development of synovial sarcoma?. Clin Sarcoma Res 2015; 5:11.
   
type journal paper/review (English)
date of publishing 15-04-2015
journal title Clin Sarcoma Res (5)
ISSN print 2045-3329
pages 11
PubMed 25922658
DOI 10.1186/s13569-015-0027-x