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EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry

Annika Nordanstig, Sami Curtze, Henrik Gensicke, Sanne M Zinkstok, Hebun Erdur, Camilla Karlsson, Jan-Erik Karlsson, Nicolas Martinez-Majander, Gerli Sibolt, Philippe Lyrer, Christopher Traenka, Merih I Baharoglu, Jan F Scheitz, Nicolas Bricout, Hilde Hénon, Didier Leys, Ashraf Eskandari, Patrik Michel, Christian Hametner, Peter Arthur Ringleb, Marcel Arnold, Urs Fischer, Hakan Sarikaya, David J Seiffge, Alessandro Pezzini, Andrea Zini, Visnja Padjen, Dejana R Jovanovic, Andreas Luft, Susanne Wegener, Lars Kellert, Katharina Feil, Georg Kägi, Alexandros Rentzos, Kimmo Lappalainen, Ronen R Leker, Jose E Cohen, John Gomori, Alex Brehm, Jan Liman, Marios Psychogios, Andreas Kastrup, Panagiotis Papanagiotou, Jan Gralla, Mauro Magoni, Charles B L M Majoie, Georg Bohner, Ivan Vukasinovic, Vladimir Cvetic, Johannes Weber, Zsolt Kulcsar, Martin Bendszus, Markus Möhlenbruch, George Ntaios, Eftychia Kapsalaki, Katarina Jood, Christian H Nolte, Paul J J Nederkoorn, Stefan Engelter, Daniel Strbian, Turgut Tatlisumak & EVA-TRISP Investigators

abstract

PURPOSE
The Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration was a concerted effort initiated in 2010 with the purpose to address relevant research questions about the effectiveness and safety of intravenous thrombolysis (IVT). The collaboration also aims to prospectively collect data on patients undergoing endovascular treatment (EVT) and hence the name of the collaboration was changed from TRISP to EVA-TRISP. The methodology of the former TRISP registry for patients treated with IVT has already been published. This paper focuses on describing the EVT part of the registry.

PARTICIPANTS
All centres committed to collecting predefined variables on consecutive patients prospectively. We aim for accuracy and completeness of the data and to adapt local databases to investigate novel research questions. Herein, we introduce the methodology of a recently constructed academic investigator-initiated open collaboration EVT registry built as an extension of an existing IVT registry in patients with acute ischaemic stroke (AIS).

FINDINGS TO DATE
Currently, the EVA-TRISP network includes 20 stroke centres with considerable expertise in EVT and maintenance of high-quality hospital-based registries. Following several successful randomised controlled trials (RCTs), many important clinical questions remain unanswered in the (EVT) field and some of them will unlikely be investigated in future RCTs. Prospective registries with high-quality data on EVT-treated patients may help answering some of these unanswered issues, especially on safety and efficacy of EVT in specific patient subgroups.

FUTURE PLANS
This collaborative effort aims at addressing clinically important questions on safety and efficacy of EVT in conditions not covered by RCTs. The TRISP registry generated substantial novel data supporting stroke physicians in their daily decision making considering IVT candidate patients. While providing observational data on EVT in daily clinical practice, our future findings may likewise be hypothesis generating for future research as well as for quality improvement (on EVT). The collaboration welcomes participation of further centres willing to fulfill the commitment and the outlined requirements.
   
citation Nordanstig A, Curtze S, Gensicke H, Zinkstok S M, Erdur H, Karlsson C, Karlsson J E, Martinez-Majander N, Sibolt G, Lyrer P, Traenka C, Baharoglu M I, Scheitz J F, Bricout N, Hénon H, Leys D, Eskandari A, Michel P, Hametner C, Ringleb P A, Arnold M, Fischer U, Sarikaya H, Seiffge D J, Pezzini A, Zini A, Padjen V, Jovanovic D R, Luft A, Wegener S, Kellert L, Feil K, Kägi G, Rentzos A, Lappalainen K, Leker R R, Cohen J E, Gomori J, Brehm A, Liman J, Psychogios M, Kastrup A, Papanagiotou P, Gralla J, Magoni M, Majoie C B L M, Bohner G, Vukasinovic I, Cvetic V, Weber J, Kulcsar Z, Bendszus M, Möhlenbruch M, Ntaios G, Kapsalaki E, Jood K, Nolte C H, Nederkoorn P J J, Engelter S, Strbian D, Tatlisumak T, EVA-TRISP Investigators . EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry. BMJ Open 2021; 11:e042211.
   
type journal paper/review (English)
date of publishing 09-08-2021
journal title BMJ Open (11/8)
ISSN electronic 2044-6055
pages e042211
PubMed 34373287
DOI 10.1136/bmjopen-2020-042211