Publication

Quantification of aortic regurgitant fraction and volume with multi-detector computed tomography comparison with echocardiography

Journal Paper/Review - Mar 1, 2011

Units
PubMed
Doi

Citation
Feuchtner G, Jaschke W, Wolf F, Scheffel H, Klauser A, Mueller S, Leschka S, Plass A, Dichtl W, Lessick J, Spoeck A, Alkadhi H. Quantification of aortic regurgitant fraction and volume with multi-detector computed tomography comparison with echocardiography. Acad Radiol 2011; 18:334-42.
Type
Journal Paper/Review (English)
Journal
Acad Radiol 2011; 18
Publication Date
Mar 1, 2011
Issn Electronic
1878-4046
Pages
334-42
Brief description/objective

RATIONALE AND OBJECTIVES
Evaluate quantification of the aortic regurgitant fraction and volume with computed tomography (CT).

MATERIALS AND METHODS
Fifty-three patients with aortic regurgitation (AR) and 29 controls were examined with 64-multi-detector CT coronary angiography and transthoracic echocardiography (TTE). A dedicated software algorithm employing three-dimensional segmentation of left ventricle (LV) and right ventricle (RV) volumes and LV mass was applied. AR volume and fraction was calculated based on RV and LV stroke volumes (SV) and compared with echocardiography. The aortic regurgitant orifice area (ROA) was measured by CT.

RESULTS
A good correlation of the AR fraction and AR volume determined by CT compared to echocardiography was found for mild, moderate, and severe AR with 14.2% ± 9, 28.8% ± 8, and 57.9% ± 9 (r = 0.95, P < .001) for AR fraction, and 15.7 mL ± 11.33 mL ± 14, and 98.9 mL ± 36 for AR volume (r = 0.92, P < .0001), respectively. CT correctly classified severity of AR in 93% of patients based of AR-fraction, and in 89% based on AR volume. The sensitivity and specificity of CT were 98% and specificity 90.3%. The specificity improved to 97%, if the ROA by CT was added as diagnostic criterion.

CONCLUSION
Aortic regurgitation fraction and volume can be accurately quantified from CT coronary angiography datasets. These parameters can assist clinical management, e.g. in case of pending cardiac surgery decision.