Pattern of failure after adjuvant radiotherapy following extrapleural pneumonectomy of pleural mesothelioma in the SAKK 17/04 trial

Publication

Pattern of failure after adjuvant radiotherapy following extrapleural pneumonectomy of pleural mesothelioma in the SAKK 17/04 trial

Journal Paper/Review - Jun 25, 2019

Riesterer Oliver, Krayenbuehl Jerome, Weder Walter, Sabrina Stark L, Zimmermann Frank, Nackaerts Kristiaan, Zwahlen Daniel R, Mahmut Ozsahin E, Plasswilm Ludwig, Aebersold Daniel M, Xyrafas Alexandros, Stahel Rolf A, Ciernik I Frank, Swiss Group for Clinical Cancer Research (SAKK)

Citation

Riesterer O, Krayenbuehl J, Weder W, Sabrina Stark L, Zimmermann F, Nackaerts K, Zwahlen D, Mahmut Ozsahin E, Plasswilm L, Aebersold D, Xyrafas A, Stahel R, Ciernik I, Swiss Group for Clinical Cancer Research (SAKK). Pattern of failure after adjuvant radiotherapy following extrapleural pneumonectomy of pleural mesothelioma in the SAKK 17/04 trial. Radiother Oncol 2019; 138:121-125.

Type

Journal Paper/Review (English)

Journal

Radiother Oncol 2019; 138

Publication Date

Jun 25, 2019

Issn Electronic

1879-0887

Pages

121-125

Brief description/objective

Postoperative radiotherapy after extrapleural pneumonectomy of malignant pleural mesothelioma was investigated in the randomized phase II trial SAKK17/04. The relapse rate within the high and/or low-dose PTV without previous distant failure was 24%, the isolated in-field-relapse rate within the PTVs was 5% and the distant relapse rate outside of the PTVs was 81%. Clinical outcome was mainly determined by distant disease progression outside of the radiation field.