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Elke Scandella

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Cheng H W, Onder L, Novkovic M, Soneson C, Lütge M, Pikor N, Scandella E, Robinson M D, Miyazaki J I, Tersteegen A, Sorg U, Pfeffer K, Rülicke T, Hehlgans T, Ludewig B. Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. Nat Commun 2019; 10:1739.
   
Perez Shibayama C, Gil Cruz C, Cheng H W, Onder L, Printz A, Mörbe U, Novkovic M, Li C, Lopez-Macias C, Buechler M B, Turley S J, Mack M, Soneson C, Robinson M D, Scandella E, Gommerman J, Ludewig B. Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity. Sci Immunol 2018; 3:.
   
Emgård J, Kammoun H, García-Cassani B, Chesné J, Parigi S M, Jacob J M, Cheng H W, Evren E, Das S, Czarnewski P, Sleiers N, Melo-Gonzalez F, Kvedaraite E, Svensson M, Scandella E, Hepworth M R, Huber S, Ludewig B, Peduto L, Villablanca E J, Veiga-Fernandes H, Pereira J P, Flavell R A, Willinger T. Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation. Immunity 2018; 48:120-132.e8.
   
Onder L, Mörbe U, Pikor N, Novkovic M, Cheng H W, Hehlgans T, Pfeffer K, Becher B, Waisman A, Rülicke T, Gommerman J, Mueller C G, Sawa S, Scandella E, Ludewig B. Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis. Immunity 2017; 47:80-92.e4.
   
Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E. Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. Elife 2016; 5:.
   
Gil Cruz C, Perez Shibayama C, Onder L, chai q, Cupovic J, Cheng H W, Novkovic M, Lang P A, Geuking M B, McCoy K D, Abe S, Cui G, Ikuta K, Scandella E, Ludewig B. Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs. Nat Immunol 2016; 17:1388-1396.
   
Novkovic M, Onder L, Cupovic J, Abe J, Bomze D, Cremasco V, Scandella E, Stein J V, Bocharov G, Turley S J, Ludewig B. Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality. PLoS Biol 2016; 14:e1002515.
   
Onder L, Nindl V, Scandella E, chai q, Cheng H W, Caviezel-Firner S, Novkovic M, Bomze D, Maier R, Mair F, Ledermann B, Becher B, Waisman A, Ludewig B. Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing presursors in the cortico-medullary junction. Eur J Immunol 2015;.
   
Perez Shibayama C, Gil Cruz C, Pastelin-Palacios R, Cervantes-Barragan L, Hisaki E, chai q, Onder L, Scandella E, Regen T, Waisman A, Isibasi A, López-Macías C, Ludewig B. IFN-γ-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi. J Immunol 2014; 192:5192-200.
   
Onder L, Danuser R, Scandella E, Firner S, chai q, Hehlgans T, Stein J V, Ludewig B. Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation. J Exp Med 2013; 210:465-73.
   
chai q, Onder L, Scandella E, Gil Cruz C, Perez Shibayama C, Cupovic J, Danuser R, Sparwasser T, Luther S A, thiel v, Rülicke T, Stein J V, Hehlgans T, Ludewig B. Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity 2013; 38:1013-24.
   
Coelho F M, Natale D, Soriano S F, Hons M, Swoger J, Mayer J, Danuser R, Scandella E, Pieczyk M, Zerwes H G, Junt T, Sailer A W, Ludewig B, Sharpe J, Figge M T, Stein J V. Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions. Blood 2013; 121:4101-9.
   
Caviezel-Firner S, Engeler D S, Bolinger B, Onder L, Scandella E, Yu M, Kroczek R A, Ludewig B. Systemic minor histocompatibility antigen expression in blood endothelial cells prevents T cell-mediated vascular immunopathology. Eur J Immunol 2013; 43:3233-43.
   
nindl v, Maier R, Ratering D, De Giuli R, Züst R, thiel v, Scandella E, Di Padova F, Kopf M, Rudin M, Rülicke T, Ludewig B. Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy. Eur J Immunol 2012; 42:2311-21.
   
Engeler D S, Scandella E, Ludewig B, Schmid H P. Ciprofloxacin and epirubicin synergistically induce apoptosis in human urothelial cancer cell lines. Urol Int 2012; 88:343-9.
   
Onder L, Narang P, Scandella E, chai q, Iolyeva M, Hoorweg K, Halin C, Richie E, Kaye P, Westermann J, Cupedo T, Coles M, Ludewig B. IL-7-producing stromal cells are critical for lymph node remodeling. Blood 2012; 120:4675-83.
   
Weber S S, Joller N, Küntzel A B, Spörri R, Tchang V S, Scandella E, Rösli C, Ludewig B, Hilbi H, Oxenius A. Identification of protective B cell antigens of Legionella pneumophila. J Immunol 2012; 189:841-9.
   
Onder L, Scandella E, chai q, Mayer C T, Sparwasser T, thiel v, Rülicke T, Ludewig B. A novel bacterial artificial chromosome-transgenic podoplanin-cre mouse targets lymphoid organ stromal cells in vivo. Front Immunol 2011; 2:50.
   
Kumar V, Scandella E, Danuser R, Onder L, Nitschké M, Fukui Y, Halin C, Ludewig B, Stein J V. Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotoxin-dependent pathway. Blood 2010; 115:4725-33.
   
Junt T, Scandella E, Ludewig B. Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence. Nature reviews. Immunology 2008; 8:764-75.
   
Scandella E, bolinger b, Lattmann E, Miller S, Favre S, Littman D R, Finke D, Luther S A, Junt T, Ludewig B. Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nature immunology 2008; 9:667-75.
   
bolinger b, Krebs P, Tian Y, Engeler D S, Scandella E, Miller S, Palmer D C, Restifo N P, Clavien P A, Ludewig B. Immunologic ignorance of vascular endothelial cells expressing minor histocompatibility antigen. Blood 2008; 111:4588-95.
   
Kang T B, Oh G S, Scandella E, bolinger b, Ludewig B, Kovalenko A, Wallach D. Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice. Journal of immunology (Baltimore, Md. : 1950) 2008; 181:2522-32.
   
Krebs P, Scandella E, bolinger b, Engeler D S, Miller S, Ludewig B. Chronic immune reactivity against persisting microbial antigen in the vasculature exacerbates atherosclerotic lesion formation. Arteriosclerosis, thrombosis, and vascular biology 2007; 27:2206-13.
   
Scandella E, Fink K, Junt T, Senn B M, Lattmann E, Förster R, Hengartner H, Ludewig B. Dendritic cell-independent B cell activation during acute virus infection: a role for early CCR7-driven B-T helper cell collaboration. Journal of immunology (Baltimore, Md. : 1950) 2007; 178:1468-76.
   
Sahin U, Türeci O, Graf C, Meyer R G, Lennerz V, Britten C M, Dumrese C, Scandella E, Wölfel T, Ludewig B. Rapid molecular dissection of viral and bacterial immunomes. European journal of immunology 2006; 36:1049-57.
   
Chen L, Gui C, Luo X, Yang Q, Günther S, Scandella E, Drosten C, Bai D, He X, Ludewig B, Chen J, Luo H, Yang Y, Yang Y, Zou J, thiel v, Chen K, Shen J, Shen X, Jiang H. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. Journal of virology 2005; 79:7095-103.
   
Waeckerle-Men Y, Allmen E U V, von Moos R, Classon B J, Scandella E, Schmid H P, Ludewig B, Groettrup M, Gillessen Sommer S. Dendritic cells generated from patients with androgen-independent prostate cancer are not impaired in migration and T-cell stimulation. The Prostate 2005; 64:323-31.
   
Maier R, Miller S, Kurrer M, Krebs P, De Giuli R, Kremer M, Scandella E, Ludewig B. Quantification and characterization of myosin peptide-specific CD4+ T cells in autoimmune myocarditis. J Immunol Methods 2005; 304:117-25.
   
Krebs P, Scandella E, Odermatt B, Ludewig B. Rapid functional exhaustion and deletion of CTL following immunization with recombinant adenovirus. Journal of immunology (Baltimore, Md. : 1950) 2005; 174:4559-66.
   
Scandella E, Men Y, Legler D F, Gillessen Sommer S, Prikler L, Ludewig B, Groettrup M. CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. Blood 2004; 103:1595-601.
   
Junt T, Scandella E, Förster R, Krebs P, Krautwald S, Lipp M, Hengartner H, Ludewig B. Impact of CCR7 on priming and distribution of antiviral effector and memory CTL. Journal of immunology (Baltimore, Md. : 1950) 2004; 173:6684-93.
   
Prikler L, Scandella E, Men Y, Engeler D S, Diener P A, Gillessen Sommer S, Ludewig B, Schmid H P. Adaptive Immuntherapie des fortgeschrittenen Prostatakarzinoms: Cancer Testis Antigene (CTA) als mögliche Zielantigene. Aktuel Urol 2004; 35:326-330.
   
Waeckerle-Men Y, Scandella E, Uetz-Von Allmen E, Ludewig B, Gillessen Sommer S, Merkle H P, Gander B, Groettrup M. Phenotype and functional analysis of human monocyte-derived dendritic cells loaded with biodegradable poly(lactide-co-glycolide) microspheres for immunotherapy. Journal of immunological methods 2004; 287:109-24.
   
Hertzig T, Scandella E, Schelle B, Ziebuhr J, Siddell S G, Ludewig B, thiel v. Rapid identification of coronavirus replicase inhibitors using a selectable replicon RNA. The Journal of general virology 2004; 85:1717-25.
   
Prikler L, Scandella E, Men Y, Engeler D S, Diener P A, Gillessen Sommer S, Ludewig B, Schmid H P. [Adaptive immunotherapy of the advanced prostate cancer - cancer testis antigen (CTA) as possible target antigens]. Aktuelle Urologie 2004; 35:326-30.
   
Ludewig B, Krebs P, Scandella E. Immunopathogenesis of atherosclerosis. Journal of leukocyte biology 2004; 76:300-6.
   
Scandella E, Men Y, Gillessen Sommer S, Förster R, Groettrup M. Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood 2002; 100:1354-61.
   
Scandella E, Eriksson K K, Hertzig T, Drosten C, Chen L, Gui C, Luo X, Shen J, Shen X, Siddell S G, Ludewig B, Jiang H, Günther S, & thiel v (2006). Identification and evaluation of coronavirus replicase inhibitors using a replicon cell line. In Advances in experimental medicine and biology (pp. 609-13): Springer.
   
 
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