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Cristina Gil Cruz

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Cheng H W, Urs M , Lütge M, Engetschwiler C, Onder L, Novkovic M, Gil Cruz C, Perez Shibayama C, Hehlgans T, Scandella E, Ludewig B. Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function. Nat Commun 2022; 13:2027.
   
Prados A, Onder L, Cheng H W, Mörbe U, Lütge M, Gil Cruz C, Perez Shibayama C, Koliaraki V, Ludewig B, Kollias G. Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity. Nat Immunol 2021; 22:510-519.
   
Ring S, Cupovic J, Onder L, Lütge M, Perez Shibayama C, Gil Cruz C, Scandella E, De Martin A, Mörbe U, Hartmann F, Wenger R, Spiegl M, Besse A, Bonilla W V, Stemeseder F, Schmidt S, Orlinger K K, Krebs P, Ludewig B, Flatz L. Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment. Nat Commun 2021; 12:4734.
   
Valero-Pacheco N, Blight J, Aldapa-Vega G, Kemlo P, Pérez-Toledo M, Wong-Baeza I, Kurioka A, Perez Shibayama C, Gil Cruz C, Sánchez-Torres L E, Pastelin-Palacios R, Isibasi A, Reyes-Sandoval A, Klenerman P, López-Macías C. Conservation of the OmpC Porin Among Typhoidal and Non-Typhoidal Serovars. Front Immunol 2020; 10:2966.
   
Pikor N, Morbe U, Lütge M, Gil Cruz C, Perez Shibayama C, Novkovic M, Cheng H W, Nombela-Arrieta C, Nagasawa T, Linterman M A, Onder L, Ludewig B. Remodeling of light and dark zone follicular dendritic cells governs germinal center responses. Nat Immunol 2020; 21:649-659.
   
Perez Shibayama C, Islander U, Lütge M, Cheng H W, Onder L, Ring S, De Martin A, Novkovic M, Colston J, Gil Cruz C, Ludewig B. Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8 T cells. Sci Immunol 2020; 5:.
   
Fässler M, Diem S, Mangana J, Hasan Ali O, Berner F, Bomze D, Ring S, Niederer R, Gil Cruz C, Perez Shibayama C, Krolik M, Siano M, Joerger M, Recher M, Risch L, Guesewell S, Risch M, Speiser D E, Ludewig B, Levesque M P, Dummer R, Flatz L. Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients. J Immunother Cancer 2019; 7:50.
   
Perez Shibayama C, Gil Cruz C, Ludewig B. Fibroblastic reticular cells at the nexus of innate and adaptive immune responses. Immunol Rev 2019; 289:31-41.
   
Zarak-Crnkovic M, Kania G, Jaźwa-Kusior A, Czepiel M, Wijnen W J, Czyż J, Müller-Edenborn B, Vdovenko D, Lindner D, Gil Cruz C, Bachmann M, Westermann D, Ludewig B, Distler O, Lüscher T F, Klingel K, Eriksson U, Błyszczuk P. Heart non-specific effector CD4 T cells protect from postinflammatory fibrosis and cardiac dysfunction in experimental autoimmune myocarditis. Basic Res Cardiol 2019; 115:6.
   
Gil Cruz C, Perez Shibayama C, De Martin A, Ronchi F, Van Der Borght K, Niederer R, Onder L, Lütge M, Novkovic M, Nindl V, Ramos G, Arnoldini M, Slack E M C, Boivin-Jahns V, Jahns R, Wyss M, Mooser C, Lambrecht B N, Maeder M T, Rickli H, Flatz L, Eriksson U, Geuking M B, McCoy K D, Ludewig B. Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy. Science 2019; 366:881-886.
   
Rieckmann M, Delgobo M, Gaal C, Büchner L, Steinau P, Reshef D, Gil Cruz C, Ter Horst E N, Kircher M, Reiter T, Heinze K G, Niessen H W, Krijnen P A, Van Der Laan A M, Piek J J, Koch C, Wester H J, Lapa C, Bauer W R, Ludewig B, Friedman N, Frantz S, Hofmann U, Ramos G C. Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses. J Clin Invest 2019; 130:.
   
Argilaguet J, Pedragosa M, Esteve-Codina A, Riera G, Vidal E, Gil Cruz C, Casella V, Andreu D, Kaisho T, Bocharov G, Ludewig B, Heath S, Meyerhans A. Systems analysis reveals complex biological processes during virus infection fate decisions. Genome Res 2019; 29:907-919.
   
Perez Shibayama C, Gil Cruz C, Cheng H W, Onder L, Printz A, Morbe U, Novkovic M, Li C, Lopez-Macias C, Buechler M B, Turley S J, Mack M, Soneson C, Robinson M D, Scandella E, Gommerman J, Ludewig B. Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity. Sci Immunol 2018; 3:.
   
Carreño J M, Perez Shibayama C, Gil Cruz C, López-Macías C, Vernazza P, Ludewig B, Albrich W. Evolution of Salmonella Typhi outer membrane protein-specific T and B cell responses in humans following oral Ty21a vaccination: A randomized clinical trial. PLoS ONE 2017; 12:e0178669.
   
Pérez-Toledo M, Valero-Pacheco N, Pastelin-Palacios R, Gil Cruz C, Perez Shibayama C, Moreno-Eutimio M A, Becker I, Pérez-Tapia S M, Arriaga-Pizano L, Cunningham A F, Isibasi A, Bonifaz L C, López-Macías C. Salmonella Typhi Porins OmpC and OmpF Are Potent Adjuvants for T-Dependent and T-Independent Antigens. Front Immunol 2017; 8:230.
   
Kindler E, Gil Cruz C, Spanier J, Li Y, Wilhelm J, Rabouw H H, Züst R, Hwang M, V'kovski P, Stalder H, Marti S, Habjan M, Cervantes-Barragan L, Elliot R, Karl N, Gaughan C, Van Kuppeveld F J M, Silverman R H, Keller M, Ludewig B, Bergmann C C, Ziebuhr J, Weiss S R, Kalinke U, Thiel V. Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication. PLoS Pathog 2017; 13:e1006195.
   
Gil Cruz C, Perez Shibayama C, Onder L, Chai Q, Cupovic J, Cheng H W, Novkovic M, Lang P A, Geuking M B, McCoy K D, Abe S, Cui G, Ikuta K, Scandella E, Ludewig B. Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs. Nat Immunol 2016; 17:1388-1396.
   
Carreño J M, Perez Shibayama C, Gil Cruz C, Printz A, Pastelin R, Isibasi A, Chariatte D, Tanoue Y, López-Macías C, Gander B, Ludewig B. PLGA-microencapsulation protects Salmonella typhi outer membrane proteins from acidic degradation and increases their mucosal immunogenicity. Vaccine 2016; 34:4263-9.
   
Cupovic J, Onder L, Gil Cruz C, Weiler E, Caviezel-Firner S, Perez Shibayama C, Rülicke T, Bechmann I, Ludewig B. Central Nervous System Stromal Cells Control Local CD8(+) T Cell Responses during Virus-Induced Neuroinflammation. Immunity 2016; 44:622-33.
   
Tschismarov R, Firner S, Gil Cruz C, Göschl L, Boucheron N, Steiner G, Matthias P, Seiser C, Ludewig B, Ellmeier W. HDAC1 controls CD8+ T cell homeostasis and antiviral response. PLoS ONE 2014; 9:e110576.
   
Perez Shibayama C, Gil Cruz C, Pastelin-Palacios R, Cervantes-Barragan L, Hisaki E, Chai Q, Onder L, Scandella E, Regen T, Waisman A, Isibasi A, López-Macías C, Ludewig B. IFN-γ-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi. J Immunol 2014; 192:5192-200.
   
Perez Shibayama C, Gil Cruz C, Ludewig B. Plasticity and complexity of B cell responses against persisting pathogens. Immunol Lett 2014; 162:53-8.
   
Chai Q, Onder L, Scandella E, Gil Cruz C, Perez Shibayama C, Cupovic J, Danuser R, Sparwasser T, Luther S A, Thiel V, Rülicke T, Stein J V, Hehlgans T, Ludewig B. Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity 2013; 38:1013-24.
   
Perez Shibayama C, Gil Cruz C, Nussbacher M, Allgäuer E, Cervantes-Barragan L, Züst R, Ludewig B. Dendritic cell-specific delivery of Flt3L by coronavirus vectors secures induction of therapeutic antitumor immunity. PLoS ONE 2013; 8:e81442.
   
Habjan M, Hubel P, Lacerda L, Benda C, Holze C, Eberl C H, Mann A, Kindler E, Gil Cruz C, Ziebuhr J, Thiel V, Pichlmair A. Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA. PLoS Pathog 2013; 9:e1003663.
   
Adan M E M, Alejandra T C, Rodolfo P P, Perez Shibayama C, Gil Cruz C, Rubén L S, Isabel B, Marcos F M, Cecilia B L, Armando I, Edmundo C, Constantino L M. Salmonella Typhi OmpS1 and OmpS2 porins are potent protective immunogens with adjuvant properties. Immunology 2013;.
   
Gil Cruz C, Perez Shibayama C, Waisman A, Bechmann I, Thiel V, Cervantes L, Ludewig B. T helper cell- and CD40-dependent germline IgM prevents chronic virus-induced demyelinating disease. Proc Natl Acad Sci USA 2012; 109:1233-8.
   
Ross E A, Coughlan R E, Flores-Langarica A, Bobat S, Marshall J L, Hussain K, Charlesworth J, Abhyankar N, Hitchcock J, Gil Cruz C, López-Macías C, Henderson I R, Khan M, Watson S P, MacLennan I C M, Buckley C D, Cunningham A F. CD31 is required on CD4+ T cells to promote T cell survival during Salmonella infection. J Immunol 2011; 187:1553-65.
   
Bobat S, Flores-Langarica A, Hitchcock J, Marshall J L, Kingsley R A, Goodall M, Gil Cruz C, Serre K, Leyton D L, Letran S E, Gaspal F, Chester R, Chamberlain J L, Dougan G, López-Macías C, Henderson I R, Alexander J, MacLennan I C M, Cunningham A F. Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection. Eur J Immunol 2011; 41:1606-18.
   
Pastelin-Palacios R, Gil Cruz C, Perez Shibayama C, Moreno-Eutimio M A, Cervantes L, Arriaga-Pizano L, Ludewig B, Cunningham A F, García-Zepeda E A, Becker I, Alpuche-Aranda C, Bonifaz L, Gunn J S, Isibasi A, López-Macías C. Subversion of innate and adaptive immune activation induced by structurally modified lipopolysaccharide from Salmonella typhimurium. Immunology 2011; 133:469-81.
   
Gil-Cruz C, Bobat S, Marshall J L, Kingsley R A, Ross E A, Henderson I R, Leyton D L, Coughlan R E, Khan M, Jensen K T, Buckley C D, Dougan G, MacLennan I C M, López-Macías C, Cunningham A F. The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response. Proc Natl Acad Sci USA 2009; 106:9803-8.
   
Cervantes-Barragán L, Gil Cruz C, Pastelin-Palacios R, Lang K S, Isibasi A, Ludewig B, López-Macías C. TLR2 and TLR4 signaling shapes specific antibody responses to Salmonella typhi antigens. Eur J Immunol 2009; 39:126-35.
   
Acosta-Ramírez E, Pérez-Flores R, Majeau N, Pastelin-Palacios R, Gil-Cruz C, Ramírez-Saldaña M, Manjarrez-Orduño N, Cervantes-Barragán L, Santos-Argumedo L, Flores-Romo L, Becker I, Isibasi A, Leclerc D, López-Macías C. Translating innate response into long-lasting antibody response by the intrinsic antigen-adjuvant properties of papaya mosaic virus. Immunology 2007; 124:186-97.
   
Secundino I, López-Macías C, Cervantes-Barragán L, Gil-Cruz C, Ríos-Sarabia N, Pastelin-Palacios R, Villasis-Keever M A, Becker I, Puente J L, Calva E, Isibasi A. Salmonella porins induce a sustained, lifelong specific bactericidal antibody memory response. Immunology 2006; 117:59-70.
   
 
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