Kantonsspital St.Gallen
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publications

Lucas Onder

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Pikor N, Mörbe U, Lütge M, Gil Cruz C, Perez Shibayama C, Novkovic M, Cheng H W, Nombela-Arrieta C, Nagasawa T, Linterman M A, Onder L, Ludewig B. Remodeling of light and dark zone follicular dendritic cells governs germinal center responses. Nat Immunol 2020; 21:649-659.
   
Choi S Y, Bae H, Jeong S H, Park I, Cho H, Hong S P, Lee D H, Lee C K, Park J S, Suh S H, Choi J, Yang M J, Jang J Y, Onder L, Moon J H, Jeong H S, Adams R H, Kim J M, Ludewig B, Song J H, Lim D S, Koh G Y. YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nat Commun 2020; 11:519.
   
Novkovic M, Onder L, Bocharov G, Ludewig B. Topological Structure and Robustness of the Lymph Node Conduit System. Cell Rep 2020; 30:893-904.e6.
   
Perez Shibayama C, Islander U, Lütge M, Cheng H W, Onder L, Ring S, De Martin A, Novkovic M, Colston J, Gil Cruz C, Ludewig B. Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8 T cells. Sci Immunol 2020; 5:.
   
Cosgrove J, Novkovic M, Albrecht S, Pikor N, Zhou Z, Onder L, Mörbe U, Cupovic J, Miller H, Alden K, Thuery A, O'Toole P, Pinter R, Jarrett S, Taylor E, Venetz D, Heller M, Uguccioni M, Legler D F, Lacey C J, Coatesworth A, Polak W G, Cupedo T, Manoury B, Thelen M, Stein J V, Wolf M, Leake M C, Timmis J, Ludewig B, Coles M C. B cell zone reticular cell microenvironments shape CXCL13 gradient formation. Nat Commun 2020; 11:3677.
   
Gil Cruz C, Perez Shibayama C, De Martin A, Ronchi F, van der Borght K, Niederer R, Onder L, Lütge M, Novkovic M, Nindl V, Ramos G, Arnoldini M, Slack E M C, Boivin-Jahns V, Jahns R, Wyss M, Mooser C, Lambrecht B N, Maeder M T, Rickli H, Flatz L, Eriksson U, Geuking M B, McCoy K D, Ludewig B. Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy. Science 2019; 366:881-886.
   
Cheng H W, Onder L, Novkovic M, Soneson C, Lütge M, Pikor N, Scandella E, Robinson M D, Miyazaki J I, Tersteegen A, Sorg U, Pfeffer K, Rülicke T, Hehlgans T, Ludewig B. Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. Nat Commun 2019; 10:1739.
   
Camara A, Cordeiro O G, Alloush F, Sponsel J, Chypre M, Onder L, Asano K, Tanaka M, Yagita H, Ludewig B, Flacher V, Mueller C G. Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche. Immunity 2019; 50:1467-1481.e6.
   
Perez Shibayama C, Gil Cruz C, Cheng H W, Onder L, Printz A, Mörbe U, Novkovic M, Li C, Lopez-Macias C, Buechler M B, Turley S J, Mack M, Soneson C, Robinson M D, Scandella E, Gommerman J, Ludewig B. Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity. Sci Immunol 2018; 3:.
   
Cheng H W, Onder L, Cupovic J, Bösch M, Novkovic M, Pikor N, Tarantino I, Rodriguez R, Schneider T, Jochum W, Brutsche M, Ludewig B. CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses. J Allergy Clin Immunol 2018;.
   
Onder L, Ludewig B. A Fresh View on Lymph Node Organogenesis. Trends Immunol 2018; 39:775-787.
   
Novkovic M, Onder L, Cheng H W, Bocharov G, Ludewig B. Integrative Computational Modeling of the Lymph Node Stromal Cell Landscape. Front Immunol 2018; 9:2428.
   
Onder L, Ludewig B. Redefining the Nature of Lymphoid Tissue Organizer Cells: Response to 'Complexity of Lymphoid Tissue Organizers' by Koning and Mebius. Trends Immunol 2018; 39:952-953.
   
Bösch M, Onder L, Cheng H W, Novkovic M, Mörbe U, Sopper S, Gastl G, Jochum W, Ruhstaller T, knauer m, Ludewig B. Interleukin 7-expressing fibroblasts promote breast cancer growth through sustenance of tumor cell stemness. Oncoimmunology 2018; 7:e1414129.
   
Novkovic M, Onder L, Bocharov G, Ludewig B. Graph Theory-Based Analysis of the Lymph Node Fibroblastic Reticular Cell Network. Methods Mol Biol 2017; 1591:43-57.
   
Chung J, Ebens C L, Perkey E, Radojcic V, Koch U, Scarpellino L, Tong A, Allen F, Wood S, Feng J, Friedman A, Granadier D, Tran I T, Chai Q, Onder L, Yan M, Reddy P, Blazar B R, Huang A Y, Brennan T V, Bishop D K, Ludewig B, Siebel C W, Radtke F, Luther S A, Maillard I. Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands. J Clin Invest 2017; 127:1574-1588.
   
Pikor N, Cupovic J, Onder L, Gommerman J L, Ludewig B. Stromal Cell Niches in the Inflamed Central Nervous System. J Immunol 2017; 198:1775-1781.
   
Onder L, Mörbe U, Pikor N, Novkovic M, Cheng H W, Hehlgans T, Pfeffer K, Becher B, Waisman A, Rülicke T, Gommerman J, Mueller C G, Sawa S, Scandella E, Ludewig B. Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis. Immunity 2017; 47:80-92.e4.
   
Savinkov R, Kislitsyn A, Watson D J, van Loon R, Sazonov I, Novkovic M, Onder L, Bocharov G. Data-driven modelling of the FRC network for studying the fluid flow in the conduit system. Engineering Applications of Artificial Intelligence 2016; 62:341-349.
   
Cupovic J, Onder L, Gil Cruz C, Weiler E, Caviezel-Firner S, Perez Shibayama C, Rülicke T, Bechmann I, Ludewig B. Central Nervous System Stromal Cells Control Local CD8(+) T Cell Responses during Virus-Induced Neuroinflammation. Immunity 2016; 44:622-33.
   
Novkovic M, Onder L, Cupovic J, Abe J, Bomze D, Cremasco V, Scandella E, Stein J V, Bocharov G, Turley S J, Ludewig B. Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality. PLoS Biol 2016; 14:e1002515.
   
Grebennikov D, van Loon R, Novkovic M, Onder L, Savinkov R, Sazonov I, Tretyakova R, J Watson D, Bocharov G. Critical Issues in Modelling Lymph Node Physiology. Computation 2016; 5:3.
   
Gil Cruz C, Perez Shibayama C, Onder L, chai q, Cupovic J, Cheng H W, Novkovic M, Lang P A, Geuking M B, McCoy K D, Abe S, Cui G, Ikuta K, Scandella E, Ludewig B. Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs. Nat Immunol 2016; 17:1388-1396.
   
Onder L, Nindl V, Scandella E, chai q, Cheng H W, Caviezel-Firner S, Novkovic M, Bomze D, Maier R, Mair F, Ledermann B, Becher B, Waisman A, Ludewig B. Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing presursors in the cortico-medullary junction. Eur J Immunol 2015;.
   
Onder L, Ludewig B. Another TLO in the Wall: Education and Control of T Cells in Atherosclerotic Arteries. Immunity 2015; 42:981-3.
   
Kislitsyn A, Savinkov R, Novkovic M, Onder L, Bocharov G. Computational Approach to 3D Modeling of the Lymph Node Geometry. Computation 2015; 3:222-234.
   
Mair F, Joller S, Hoeppli R, Onder L, Hahn M, Ludewig B, Waisman A, Becher B. The NFκB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing γδ T cells. Elife 2015; 4:.
   
Perez Shibayama C, Gil Cruz C, Pastelin-Palacios R, Cervantes-Barragan L, Hisaki E, chai q, Onder L, Scandella E, Regen T, Waisman A, Isibasi A, López-Macías C, Ludewig B. IFN-γ-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi. J Immunol 2014; 192:5192-200.
   
Cremasco V, Woodruff M C, Onder L, Cupovic J, Nieves-Bonilla J M, Schildberg F A, Chang J, Cremasco F, Harvey C J, Wucherpfennig K, Ludewig B, Carroll M C, Turley S J. B cell homeostasis and follicle confines are governed by fibroblastic reticular cells. Nat Immunol 2014; 15:973-81.
   
Astarita J L, Cremasco V, Fu J, Darnell M C, Peck J R, Nieves-Bonilla J M, Song K, Kondo Y, Woodruff M C, Gogineni A, Onder L, Ludewig B, Weimer R M, Carroll M C, Mooney D J, Xia L, Turley S J. The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture. Nat Immunol 2014; 16:75-84.
   
Fasnacht N, Huang H Y, Koch U, Favre S, Auderset F, chai q, Onder L, Kallert S, Pinschewer D D, MacDonald H R, Tacchini-Cottier F, Ludewig B, Luther S A, Radtke F. Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses. J Exp Med 2014; 211:2265-79.
   
Onder L, Danuser R, Scandella E, Firner S, chai q, Hehlgans T, Stein J V, Ludewig B. Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation. J Exp Med 2013; 210:465-73.
   
Iolyeva M, Aebischer D, Proulx S T, Willrodt A H, Ecoiffier T, Häner S, Bouchaud G, Krieg C, Onder L, Ludewig B, Santambrogio L, Boyman O, Chen L, Finke D, Halin C. Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage. Blood 2013; 122:2271-81.
   
chai q, Onder L, Scandella E, Gil Cruz C, Perez Shibayama C, Cupovic J, Danuser R, Sparwasser T, Luther S A, thiel v, Rülicke T, Stein J V, Hehlgans T, Ludewig B. Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity 2013; 38:1013-24.
   
Caviezel-Firner S, Engeler D S, Bolinger B, Onder L, Scandella E, Yu M, Kroczek R A, Ludewig B. Systemic minor histocompatibility antigen expression in blood endothelial cells prevents T cell-mediated vascular immunopathology. Eur J Immunol 2013; 43:3233-43.
   
Onder L, Narang P, Scandella E, chai q, Iolyeva M, Hoorweg K, Halin C, Richie E, Kaye P, Westermann J, Cupedo T, Coles M, Ludewig B. IL-7-producing stromal cells are critical for lymph node remodeling. Blood 2012; 120:4675-83.
   
Onder L, nindl v, Ludewig B. Tight control - decision-making during T cell-vascular endothelial cell interaction. Front Immunol 2012; 3:279.
   
Onder L, Scandella E, chai q, Mayer C T, Sparwasser T, thiel v, Rülicke T, Ludewig B. A novel bacterial artificial chromosome-transgenic podoplanin-cre mouse targets lymphoid organ stromal cells in vivo. Front Immunol 2011; 2:50.
   
Kumar V, Scandella E, Danuser R, Onder L, Nitschké M, Fukui Y, Halin C, Ludewig B, Stein J V. Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotoxin-dependent pathway. Blood 2010; 115:4725-33.
   
Zinkernagel M S, bolinger b, Krebs P, Onder L, Miller S, Ludewig B. Immunopathological basis of lymphocytic choriomeningitis virus-induced chorioretinitis and keratitis. Journal of virology 2009; 83:159-66.
   
 
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