Publication
Immune-checkpoint inhibitors associated with interstitial lung disease in cancer patients
Journal Paper/Review - Aug 10, 2017
Delaunay Myriam, Campana Marion, Gautschi Oliver, Früh Martin, Fumet Jean-David, Audigier-Valette Clarisse, Couraud Sébastien, Dalle Stéphane, Leccia Marie-Thérèse, Jaffro Marion, Collot Samia, Prévot Grégoire, Milia Julie, Pérol Maurice, Dansin Eric, Cadranel Jacques, Lusque Amélie, Meyer Nicolas, Gounant Valérie, Moro-Sibilot Denis, Michot Jean-Marie, Raimbourg Judith, Girard Nicolas, Guisier Florian, Planchard David, Metivier Anne-Cécile, Tomasini Pascale, Mazières Julien
Units
PubMed
Doi
Citation
Type
Journal
Publication Date
Issn Electronic
Brief description/objective
Immunotherapy is becoming a standard of care for many cancers. Immune-checkpoint inhibitors (ICI) can generate immune-related adverse events. Interstitial lung disease (ILD) has been identified as a rare but potentially severe event.Between December 2015 and April 2016, we conducted a retrospective study in centres experienced in ICI use. We report the main features of ICI-ILD with a focus on clinical presentation, radiological patterns and therapeutic strategies.We identified 64 (3.5%) out of 1826 cancer patients with ICI-ILD. Patients mainly received programmed cell death-1 inhibitors. ILD usually occurred in males, and former or current smokers, with a median age of 59 years. We observed 65.6% grade 2/3 severity, 9.4% grade 4 severity and 9.4% fatal ILD. The median (range) time from initiation of immunotherapy to ILD was 2.3 (0.2-27.4) months. Onset tended to occur earlier in lung cancer versus melanoma: median 2.1 and 5.2 months, respectively (p=0.02). Ground-glass opacities (81.3%) were the predominant lesions, followed by consolidations (53.1%). Organising pneumonia (23.4%) and hypersensitivity pneumonitis (15.6%) were the most common patterns. Overall survival at 6 months was 58.1% (95% CI 37.7-73.8%).ICI-ILD often occurs early and displays suggestive radiological features. As there is no clearly identified risk factor, oncologists need to diagnose and adequately treat this adverse event.