Publication

Systems analysis reveals complex biological processes during virus infection fate decisions

Journal Paper/Review - May 28, 2019

Units
PubMed
Doi

Citation
Argilaguet J, Heath S, Ludewig B, Bocharov G, Kaisho T, Andreu D, Casella V, Gil Cruz C, Vidal E, Riera G, Esteve-Codina A, Pedragosa M, Meyerhans A. Systems analysis reveals complex biological processes during virus infection fate decisions. Genome Res 2019; 29:907-919.
Type
Journal Paper/Review (English)
Journal
Genome Res 2019; 29
Publication Date
May 28, 2019
Issn Electronic
1549-5469
Pages
907-919
Brief description/objective

The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an alleviated immune response and chronic infection are poorly understood. Here, we characterized the host response to acute and chronic lymphocytic choriomeningitis virus (LCMV) infections by gene coexpression network analysis of time-resolved splenic transcriptomes. First, we found an early attenuation of inflammatory monocyte/macrophage prior to the onset of T cell exhaustion, and second, a critical role of the XCL1-XCR1 communication axis during the functional adaptation of the T cell response to the chronic infection state. These findings not only reveal an important feedback mechanism that couples T cell exhaustion with the maintenance of a lower level of effector T cell response but also suggest therapy options to better control virus levels during the chronic infection phase.