Kantonsspital St.Gallen

Abscopal effect in lung cancer: three case reports and a concise review

Elena Garelli, Achim Rittmeyer , Paul Martin Putora, Markus Glatzer, Ralf Dressel & Stefan Andreas

abstract The abscopal effect describes the ability of locally administered radiotherapy to induce systemic antitumor effects. Over the past 40 years, reports on the abscopal effect following conventional radiation have been relatively rare, especially in less immunogenic tumors such as lung cancer. However, with the continued development and use of immunotherapy, reports on the abscopal effect have become increasingly frequent during the last decade. Here, we present three illustrative case reports from our own institution and previous published cases of the abscopal effect in patients with non-small cell lung cancer, treated with immune checkpoint inhibitors and radiotherapy. We also present a concise review of the clinical and experimental literature on the abscopal effect in non-small cell lung cancer.
citation Garelli E, Rittmeyer A, Putora P M, Glatzer M, Dressel R, Andreas S. Abscopal effect in lung cancer: three case reports and a concise review. Immunotherapy 2019; 11:1445-1461.
type journal paper/review (English)
date of publishing 12-2019
journal title Immunotherapy (11/17)
ISSN electronic 1750-7448
pages 1445-1461
PubMed 31826745
DOI 10.2217/imt-2019-0105