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A Fresh View on Lymph Node Organogenesis

Lucas Onder & Burkhard Ludewig

abstract Lymph nodes (LNs) are strategically positioned outposts of the immune system that underpin regional immune surveillance. The current model describing LN formation in mice is based on a two cell-type interaction scheme with lymphoid tissue inducer cells regulating the activation of mesenchymal lymphoid tissue organizer cells. We highlight here the key role of lymphatic endothelial cells during the initiation of LN formation. The involvement of lymphatic endothelial cells as an additional organizer cell type in LN organogenesis unveils multiple control levels that govern the generation of lymphoid organs. Moreover, the linkage between lymphangiogenic and lymphvasculogenic processes and guidance of the accumulation and activation of lymphoid tissue inducer cells in the embryo suggests that LN formation may be driven on demand by developing organ systems.
   
citation Onder L, Ludewig B. A Fresh View on Lymph Node Organogenesis. Trends Immunol 2018; 39:775-787.
   
type journal paper/review (English)
date of publishing 24-08-2018
journal title Trends Immunol (39/10)
ISSN electronic 1471-4981
pages 775-787
PubMed 30150089
DOI 10.1016/j.it.2018.08.003