Publication

B cells in MS: Why, where and how?

Journal Paper/Review - Apr 7, 2012

Units
PubMed
Doi

Citation
Pikor N, Gommerman J. B cells in MS: Why, where and how?. Mult Scler Relat Disord 2012; 1:123-30.
Type
Journal Paper/Review (English)
Journal
Mult Scler Relat Disord 2012; 1
Publication Date
Apr 7, 2012
Issn Print
2211-0348
Pages
123-30
Brief description/objective

Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS), in which auto-aggressive lymphocytes participate in inflammation that causes myelin destruction. Although T lymphocytes have been viewed as important culprits in the inflammatory cascade that results in MS, clinical trial results and animal model data support a role for B lymphocytes in MS pathology. In spite of these encouraging results, the mechanism behind why B cell depletion might be effective for MS treatment remains unknown. Herein we summarize the state of our knowledge for how B cells and their antibody products may influence the initiation and or propagation of MS, drawing from human studies and animal model data.