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Laryngopharyngeal reflux in chronic obstructive pulmonary disease - a multi-centre study

Julia Sanchez, Desiree M Schumann, Meropi Karakioulaki, Eleni Papakonstantinou, Frank Rassouli, Matthias Frasnelli, Martin Brutsche, Michael Tamm & Daiana Stolz

abstract Reflux of gastric content has been associated with recurrent exacerbations of chronic obstructive pulmonary disease (COPD). We aimed to assess the prevalence of laryngopharyngeal reflux (LPR) in COPD and if LPR is a contributing factor to clinically relevant outcomes in COPD. We evaluated a total of 193 COPD patients (GOLD I-IV) with a 24-h laryngo-pharyngeal pΗ-monitor. LPR was observed in 65.8% of COPD patients and it was not significantly associated with clinically relevant outcomes of COPD. Treatment with PPI significantly decreased the upright RYAN score (p = 0.047) without improving lung function. Furthermore, the presence or severity of LPR cannot be diagnosed based solely on symptoms and questionnaires.
   
citation Sanchez J, Schumann D M, Karakioulaki M, Papakonstantinou E, Rassouli F, Frasnelli M, Brutsche M, Tamm M, Stolz D. Laryngopharyngeal reflux in chronic obstructive pulmonary disease - a multi-centre study. Respir Res 2020; 21:220.
   
type journal paper/review (English)
date of publishing 21-08-2020
journal title Respir Res (21/1)
ISSN electronic 1465-993X
pages 220
PubMed 32825819
DOI 10.1186/s12931-020-01473-2