Publication

Metastatic bone pain: treatment options with an emphasis on bisphosphonates

Journal Paper/Review - Oct 1, 2008

Units
PubMed
Doi

Citation
von Moos R, Strasser F, Gillessen Sommer S, Zaugg K. Metastatic bone pain: treatment options with an emphasis on bisphosphonates. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2008; 16:1105-15.
Type
Journal Paper/Review (English)
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2008; 16
Publication Date
Oct 1, 2008
Issn Print
0941-4355
Pages
1105-15
Brief description/objective

INTRODUCTION: One of the key targets for metastatic cancer cells is the skeleton. Once metastatic cells are established within the bone matrix, skeletal integrity becomes increasingly compromised. Bone lesions lead to various complications, including bone pain, fractures and spinal cord compression. MECHANISMS OF BONE PAIN: Bone pain is debilitating and affects quality of life of the patient. In addition, it increases the use of health care resources. Many patients with metastatic bone disease experience substantial bone pain despite state-of-the-art systemic analgesic treatment. Incident pain is the predominant pain syndrome. TREATMENT OPTIONS FOR BONE PAIN: Typically, this syndrome requires moderate baseline analgesia with increased on-demand doses. Other techniques for treating bone pain, including radiation therapy, neuraxial application of analgesics, nerve blocks and local stabilisation procedures, should be considered. In addition, therapy with bisphosphonates targeting bone-specific pain is an important strategy. This review discusses the various management options for bone pain arising from metastatic bone disease.