Kantonsspital St.Gallen
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Prognostic factors for the malignant triton tumor of the head and neck

Andrej Terzic, Beata Bode, Klaus W Gratz & Sandro Stöckli

abstract BACKGROUND: Malignant triton tumors are rare neoplasias consisting of a malignant peripheral nerve sheath tumor with additional rhabdomyoblastic differentiation. These tumors are highly aggressive and prognosis is poor. Our aim is to describe the outcome and to identify potential prognostic factors. METHODS: From 1993 to 2005, 7 patients with a malignant triton tumor of the head and neck were treated at our institution. A literature search revealed another 46 published cases. All these cases were analyzed for outcome and prognostic factors. RESULTS: Patients with primary tumors involving the nose and paranasal sinuses have better, patients involving the neck a poor prognosis. All other locations show an intermediate course. Complete surgical removal is of crucial importance. Additional radiation or chemotherapy show little effect. CONCLUSION: Location of the primary tumor is a key factor for prognosis. Complete surgical removal is the only treatment associated with survival.
   
citation Terzic A, Bode B, Gratz K W, Stöckli S. Prognostic factors for the malignant triton tumor of the head and neck. Head & neck 2009; 31:679-88.
   
type journal paper/review (English)
date of publishing 5-2009
journal title Head & neck (31/5)
ISSN electronic 1097-0347
pages 679-88
PubMed 19283843
DOI 10.1002/hed.21051