Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery

Publication

Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery

Journal Paper/Review - Jul 10, 2017

Broglie Däppen Martina, Müller Martin, Spreitzer Stefan, Lang Florian, Lutchmaya Mathieu, Stauffer Edouard, Espeli Vittoria, Martucci Francesco, Bongiovanni Massimo, Foerbs Diana, Arnoux Andre, Dettmer Matthias, Arnold Andreas, Stöckli Sandro, Sauter Rafael, Pasche Philippe, Reinhard Antoine, de Leval Laurence, Huber Gerhard F, Pezier Thomas F, Soltermann Alex, Giger Roland, Jochum Wolfram

Citation

Broglie Däppen M, Müller M, Spreitzer S, Lang F, Lutchmaya M, Stauffer E, Espeli V, Martucci F, Bongiovanni M, Foerbs D, Arnoux A, Dettmer M, Arnold A, Stöckli S, Sauter R, Pasche P, Reinhard A, de Leval L, Huber G, Pezier T, Soltermann A, Giger R, Jochum W. Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery. Head & neck 2017; 39:2004-2015.

Type

Journal Paper/Review (English)

Journal

Head & neck 2017; 39

Publication Date

Jul 10, 2017

Issn Electronic

1097-0347

Pages

2004-2015

Brief description/objective

BACKGROUND
Knowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC.

METHODS
Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors.

RESULTS
The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P = .01; DSS 92% vs 76%; P = .03). Patients in the low-risk category had higher survival rates (OS 91%; DSS 99%) than patients in the intermediate-risk group (OS 63%; DSS 83%), and high-risk group (OS 61%; DSS 75%).

CONCLUSION
Nonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone.