Kantonsspital St.Gallen

Indeterminate dendritic cell tumor in the pancreas

Rosita Sortino, Michael Schmid, Yassir El Baz, Antonia Loosen, Ignazio Tarantino, Thomas Steffen, Bruno Schmied & Fariba Abbassi

abstract Indeterminate dendritic cell tumor (IDCT) is an extremely rare hematologic neoplastic disorder with proliferation of indeterminate dendritic cells. In the vast majority of cases, IDCTs are restricted to the skin or lymph nodes. To our knowledge, we report the first case of IDCT in the pancreas. Due to the rarity of extracutaneous IDCT, guidelines or treatment recommendations addressing their management are missing. We performed a review of literature to compare our experience to the management of other extracutaneous IDCT. Histopathological examination confirms the diagnosis of IDCT in electron microscopy and/or immunohistochemistry. Specific features are the lack of Birbeck granules and the nonreaction to Langerin antibodies. Concerning the aftercare of extracutaneous IDCT, we recommend a dermatological examination to rule out an additional cutaneous manifestation as well as annual blood examinations due to the association between IDCT and hematologic malignancies.
citation Sortino R, Schmid M, El Baz Y, Loosen A, Tarantino I, Steffen T, Schmied B, Abbassi F. Indeterminate dendritic cell tumor in the pancreas. J Surg Case Rep 2020; 2020:rjaa208.
type journal paper/review (English)
date of publishing 16-7-2020
journal title J Surg Case Rep (2020/7)
ISSN print 2042-8812
pages rjaa208
PubMed 32714504
DOI 10.1093/jscr/rjaa208
contact Ulrich Beutner