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Intratumoral plasmacytoid dendritic cells associate with increased survival in patients with follicular lymphoma

Raphael Butsch, Stephan Wälti, Sarah Schaerer, Julia Braun, Dimitri Korol, Nicole Probst-Hensch, Holger Moch & Michael Kurrer

abstract Gene array studies on follicular lymphoma (FL) have associated non-malignant tumor-infiltrating immune cells with patient survival. We examined the role of such cells detectable by immunohistochemistry in a tissue microarray, focusing on plasmacytoid dendritic cells (pDCs). These cells physiologically produce interferon-α, which has been used in the therapy of FL. High numbers of pDCs are associated with increased survival, and so are high numbers of CD3+ T cells. The regular distribution of pDCs within T cell areas is reflected by a weak but significant correlation between pDCs and T cells. However, in multivariate Cox models, CD123 proved to be an independent prognostic factor. These findings support the hypothesis of an association of pDCs with better prognosis by producing interferon. Furthermore, due to a linear relationship between pDCs and survival shown by means of Kaplan-Meier plots, immunohistochemical staining of CD123 could serve as a prognostic tool for patients with FL.
   
citation Butsch R, Wälti S, Schaerer S, Braun J, Korol D, Probst-Hensch N, Moch H, Kurrer M. Intratumoral plasmacytoid dendritic cells associate with increased survival in patients with follicular lymphoma. Leuk Lymphoma 2011; 52:1230-8.
   
type journal paper/review (English)
date of publishing 23-05-2011
journal title Leuk Lymphoma (52/7)
ISSN electronic 1029-2403
pages 1230-8
PubMed 21599580
DOI 10.3109/10428194.2011.569619